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NAC and Raynaud's phenomenon and systemic sclerosis (scleroderma)

1 message in topic  
1 nac   2001-11-28 10:09

Intravenous N-Acetylcysteine for Treatment of
Raynaud's Phenomenon Secondary to Systemic Sclerosis: A Pilot Study

PAOLA SAMBO, DONATELLA AMICO, ROBERTO GIACOMELLI,
MARCO MATUCCI-CERINIC, FELICE SALSANO, GABRIELE
VALENTINI, and ARMANDO GABRIELLI
J Rheumatol 2001 Oct;28(10):2257-62

http://www.jrheum.com/abstracts/abstracts01/2257.html
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list _uids=11669166

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*Raynaud's phenomenon attacks decreased significantly compared to pretreatment values
*Active ulcers were significantly less numerous at all followup visits
*In the cold challenge test mean recovery time fell by 69.56%, ...

*N-acetylcysteine appears to be safe for the treatment of RP secondary to SSc.
*These preliminary data warrant further controlled studies.
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Further reading :
* http://www.sclero.org/medical/about-sd/a-to-z.html
* http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list _uids=9886268


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